METHAMPHETAMINE-INDUCED EXPRESSION OF INTERLEUKIN-1-BETA MESSENGER-RNA IN THE RAT HYPOTHALAMUS

被引：62

作者：

YAMAGUCHI, T

KURAISHI, Y

MINAMI, M

NAKAI, S

HIRAI, Y

SATOH, M

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KYOTO 606,JAPAN

[2] OTSUKA PHARMACEUT CO LTD,INST CELLULAR TECHNOL,TOKUSHIMA,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 128卷 / 01期

关键词：

INTERLEUKIN-1-BETA; MESSENGER RNA; METHAMPHETAMINE; HYPOTHALAMUS; CATECHOLAMINE; NORTHERN BLOT ANALYSIS; CENTRAL NERVOUS-SYSTEM; TUMOR NECROSIS FACTOR; NEURONS; REGION;

D O I：

10.1016/0304-3940(91)90766-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of methampethamine on the expression of interleukin-1-beta-(IL-1-beta) mRNA in the rat brain was investigated with Northern blot analysis. Methamphetamine (2-15 mg/kg, i.p.) caused a marked induction of IL-1-beta mRNA in the hypothalamus among the 8 brain regions examined, in a dose-dependent manner. The level of IL-1-beta mRNA reached a maximum at 1 h and rapidly declined within 2 h after the injection of 15 mg/kg. These results provide the first evidence that methamphetamine induces the expression of IL-1-beta mRNA in the hypothalamus, which may be partly involved in the production of central actions of this drug.

引用

页码：90 / 92

页数：3

共 18 条

[1] CORTICOTROPIN-RELEASING FACTOR PRODUCING NEURONS IN THE RAT ACTIVATED BY INTERLEUKIN-1 [J].