共 31 条
[31]
VANSLEGTENHORST MA, 1994, HUM MOL GENET, V3, P547
DIFFERENT CHROMOSOMAL LOCALIZATION OF THE CLCN4 GENE IN MUS-SPRETUS AND C57BL/6J MICE
被引：74
作者：
RUGARLI, EI
ADLER, DA
BORSANI, G
TSUCHIYA, K
FRANCO, B
HAUGE, X
DISTECHE, C
CHAPMAN, V
BALLABIO, A
机构：
[1] TELETHON INST GENET & MED,MILAN,ITALY
[2] UNIV WASHINGTON,DEPT PATHOL,SEATTLE,WA 98195
[3] BAYLOR COLL MED,DEPT MOLEC & HUMAN GENET,HOUSTON,TX 77030
[4] ROSWELL PK CANC INST,DEPT MOLEC & CELL BIOL,BUFFALO,NY 14263
[5] UNIV SIENA,DEPT MOLEC BIOL,SIENA,ITALY
关键词：
D O I：
10.1038/ng0895-466
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ;
090102 ;
摘要：
We report the unprecedented finding of a gene with a different map position in two mouse strains. The Clcn4 gene was found to map to the X chromosome in the wild Mediterrean mouse, Mus spretus but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region, Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.
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页码：466 / 471
页数：6
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