ANTIHEMORRHAGIC FACTORS FROM THE BLOOD-SERUM OF THE WESTERN DIAMONDBACK RATTLESNAKE CROTALUS-ATROX

被引：41

作者：

WEISSENBERG, S

OVADIA, M

FLEMINGER, G

KOCHVA, E

机构：

[1] TEL AVIV UNIV, GEORGE S WISE FAC LIFE SCI, DEPT BIOTECHNOL, IL-69978 TEL AVIV, ISRAEL

[2] OPEN UNIV ISRAEL, IL-61392 TEL AVIV, ISRAEL

来源：

TOXICON | 1991年 / 29卷 / 07期

关键词：

D O I：

10.1016/0041-0101(91)90217-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several antihemorrhagic factors isolated from C. atrox serum are glycoproteins with mol. wt ranging from 65,000 to 80,000. The antihemorrhagic activity of these factors was stable at a pH range of 1.3-11.5 and at temperatures up to 85-degrees-C, for 30 min. The isolated antihemorrhagins also neutralized the proteolytic activity of C. atrox venom, as tested with azocollagen and gelatin, and formed a complex with hemorrhagic toxin e isolated from the same venom. The neutralization capacity of the isolated antihemorrhagins was six times as high as the commercial polyvalent antivenom produced for clinical use.

引用

页码：807 / 818

页数：12