RECEPTOR-BASED DESIGN OF DIHYDROFOLATE-REDUCTASE INHIBITORS - COMPARISON OF CRYSTALLOGRAPHICALLY DETERMINED ENZYME BINDING WITH ENZYME AFFINITY IN A SERIES OF CARBOXY-SUBSTITUTED TRIMETHOPRIM ANALOGS

被引：65

作者：

KUYPER, LF ^{[1
]}

ROTH, B ^{[1
]}

BACCANARI, DP ^{[1
]}

FERONE, R ^{[1
]}

BEDDELL, CR ^{[1
]}

CHAMPNESS, JN ^{[1
]}

STAMMERS, DK ^{[1
]}

DANN, JG ^{[1
]}

NORRINGTON, FE ^{[1
]}

BAKER, DJ ^{[1
]}

GOODFORD, PJ ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 03期

关键词：

D O I：

10.1021/jm00381a008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：303 / 311

页数：9

共 59 条

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[6] THE BINDING OF TRIMETHOPRIM TO BACTERIAL DIHYDROFOLATE-REDUCTASE [J].

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[9] SPECIES-DIFFERENCES IN THE BINDING OF COMPOUNDS DESIGNED TO FIT A SITE OF KNOWN STRUCTURE IN ADULT HUMAN HEMOGLOBIN [J].

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[10] COMPOUNDS DESIGNED TO FIT A SITE OF KNOWN STRUCTURE IN HUMAN HEMOGLOBIN [J].

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