PHENOTYPIC AND FUNCTIONAL STAGES IN THE INTRATHYMIC DEVELOPMENT OF ALPHA-BETA-T-CELLS

被引：175

作者：

NIKOLICZUGIC, J

机构：

[1] Dept of Immunology, Sloan-Kettering Institute, New York, NY 10021

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 02期

关键词：

D O I：

10.1016/0167-5699(91)90160-U

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The thymus is the main site of T-cell maturation. On arrival in the thymus, CD8-CD4- double-negative (DN) T-cell precursors undergo extensive gene rearrangement, phenotypic alteration and biochemical modification to yield the population of thymocytes that undergoes intrathymic selection. The selected mature thymocytes then go on to seed the periphery. In this article Janko Nikolic-Zugic discusses the labyrinthine development that constitutes alpha-beta-T-cell maturation and selection.

引用

收藏

页码：65 / 70

页数：6

相关论文

共 65 条

[1]

BALLAS ZK, 1990, J IMMUNOL, V145, P1039

[2] POSITIVE SELECTION OF THE T-CELL REPERTOIRE - WHERE AND WHEN DOES IT OCCUR [J].

BENOIST, C ;

MATHIS, D .

CELL, 1989, 58 (06) :1027-1033

[3] PHENOTYPIC DIFFERENCES BETWEEN ALPHA-BETA-T-CELL VERSUS BETA-T-CELL RECEPTOR TRANSGENIC MICE UNDERGOING NEGATIVE SELECTION [J].

BERG, LJ ;

FAZEKAS DE ST GROTH, B ;

PULLEN, AM ;

DAVIS, MM .

NATURE, 1989, 340 (6234) :559-562

[4] THE EFFECTS OF MHC GENE DOSAGE AND ALLELIC VARIATION ON T-CELL RECEPTOR SELECTION [J].

BERG, LJ ;

FRANK, GD ;

DAVIS, MM .

CELL, 1990, 60 (06) :1043-1053

[5] RADIATION CHIMAERA, HOST H-2 ANTIGENS DETERMINE IMMUNE RESPONSIVENESS OF DONOR CYTOTOXIC CELLS [J].

BEVAN, MJ .

NATURE, 1977, 269 (5627) :417-418

[6] CHARACTERIZATION OF MURINE THYMOCYTES WITH CD3-ASSOCIATED T-CELL RECEPTOR STRUCTURES [J].

BLUESTONE, JA ;

PARDOLL, D ;

SHARROW, SO ;

FOWLKES, BJ .

NATURE, 1987, 326 (6108) :82-84

[7] DEVELOPMENTALLY REGULATED EXPRESSION OF T-CELL RECEPTOR BETA-CHAIN VARIABLE DOMAINS IN IMMATURE THYMOCYTES [J].

BUDD, RC ;

MIESCHER, GC ;

HOWE, RC ;

LEES, RK ;

BRON, C ;

MACDONALD, HR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (02) :577-582

[8]

CALLAHAN JE, 1990, J IMMUNOL, V144, P2473

[9] INDUCTION OF CYTO-TOXIC LYMPHOCYTES-T BY PRIMARY INVITRO STIMULATION WITH PEPTIDES [J].

CARBONE, FR ;

MOORE, MW ;

SHEIL, JM ;

BEVAN, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (06) :1767-1779

[10] EXPRESSION OF INTERLEUKIN-2 RECEPTORS AS A DIFFERENTIATION MARKER ON INTRATHYMIC STEM-CELLS [J].

CEREDIG, R ;

LOWENTHAL, JW ;

NABHOLZ, M ;

MACDONALD, HR .

NATURE, 1985, 314 (6006) :98-100

← 1 2 3 4 5 6 7 →