PHENOTYPIC AND FUNCTIONAL STAGES IN THE INTRATHYMIC DEVELOPMENT OF ALPHA-BETA-T-CELLS

被引：175

作者：

NIKOLICZUGIC, J

机构：

[1] Dept of Immunology, Sloan-Kettering Institute, New York, NY 10021

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 02期

关键词：

D O I：

10.1016/0167-5699(91)90160-U

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The thymus is the main site of T-cell maturation. On arrival in the thymus, CD8-CD4- double-negative (DN) T-cell precursors undergo extensive gene rearrangement, phenotypic alteration and biochemical modification to yield the population of thymocytes that undergoes intrathymic selection. The selected mature thymocytes then go on to seed the periphery. In this article Janko Nikolic-Zugic discusses the labyrinthine development that constitutes alpha-beta-T-cell maturation and selection.

引用

页码：65 / 70

页数：6

共 65 条

[61] THYMIC MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS AND THE ALPHA-BETA-T-CELL RECEPTOR DETERMINE THE CD4/CD8 PHENOTYPE OF T-CELLS [J].