GLYCINE, GLYCYL GLYCINE AND MALTODEXTRIN BASED ORAL REHYDRATION SOLUTION - ASSESSMENT OF EFFICACY AND SAFETY IN COMPARISON TO STANDARD ORS

被引:17
作者
BHAN, MK [1 ]
SAZAWAL, S [1 ]
BHATNAGAR, S [1 ]
BHANDARI, N [1 ]
GUHA, DK [1 ]
AGGARWAL, SK [1 ]
机构
[1] KASTURBA GANDHI HOSP, DEPT PEDIAT, NEW DELHI, INDIA
来源
ACTA PAEDIATRICA SCANDINAVICA | 1990年 / 79卷 / 05期
关键词
diarrhoea; diarrhoea treatment; ORS;
D O I
10.1111/j.1651-2227.1990.tb11506.x
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
We evaluated the efficacy and safety of an oral rehydration solution containing glycyl-glycine, glycine, and maltodextrin (GGG-ORS), in comparison to the glucose based ORS (standard ORS). The osmolality of the GGG-ORS (305 mOsm/l) and standard ORS (311 mOsm/l) was similar. Ninety-two children presenting with acute gastroenteritis and moderate dehydration, aged 3 months to 3 years, were randomly assigned to receive standard ORS or GGG-ORS. All the patients were successfully rehydrated orally. The two groups were comparable for baseline characteristics including the microbial etiology. Rotavirus (49%, 36%), ETEC (11%, 18%) or a combination of rotavirus and ETEC (15%, 9%) were the main stool pathogens isolated. There was no significant difference in the mean stool output or duration of diarrhoea between the two groups. Patients in the GGG-ORS group had higher urine output (p<0.01) and weight gain (p<0.05) in the initial 6 hours when feeding was withheld, but no such differences were observed beyond this period. Hypernatremia did not develop in any patient during the study. We conclude that glycine and glycyl-glycine supplemented oral rehydration solution does not have any therapeutic advantage in the treatment of acute gastroenteritis with moderate dehydration caused predominantly by rotavirus.
引用
收藏
页码:518 / 526
页数:9
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