TCP PILUS BIOSYNTHESIS IN VIBRIO-CHOLERAE O1 - GENE SEQUENCE OF TCPC ENCODING AN OUTER-MEMBRANE LIPOPROTEIN

被引：18

作者：

OGIERMAN, MA ^{[1
]}

MANNING, PA ^{[1
]}

机构：

[1] UNIV ADELAIDE, DEPT MICROBIOL & IMMUNOL, ADELAIDE, SA 5001, AUSTRALIA

来源：

FEMS MICROBIOLOGY LETTERS | 1992年 / 97卷 / 1-2期

关键词：

COLONIZATION; ADHERENCE; FIMBRIAE; VIBRIO-CHOLERAE;

D O I：

10.1016/0378-1097(92)90383-Y

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nucleotide sequence of the tcpC gene has been determined. It encodes a 53995-Da protein precursor with a signal sequence and cleavage site typical of a number of outer membrane lipoproteins, which are cleaved by the equivalent of signal peptidase II (Lsp) of Escherichia coli. The location of the tcpC gene is such that it is predicted to be translationally coupled to the 5' and 3' flanking genes, tcpY and tcpD, respectively, indicating that it forms part of an operon. Together with the lipoprotein signal sequence and the several hydrophobic domains it seems likely that TcpC is a surface-anchored trans-outer membrane lipoprotein.

引用

页码：179 / 184

页数：6

共 29 条

[1] A BACTERIAL VIRULENCE DETERMINANT ENCODED BY LYSOGENIC COLIPHAGE-LAMBDA [J].

BARONDESS, JJ ;

BECKWITH, J .

NATURE, 1990, 346 (6287) :871-874

[2]

BROOMESMITH JK, 1989, MOL MICROBIOL, V3, P1277

[3] CLONING AND DNA-SEQUENCE OF PLASMID DETERMINANT ISS, CODING FOR INCREASED SERUM SURVIVAL AND SURFACE EXCLUSION, WHICH HAS HOMOLOGY WITH LAMBDA DNA [J].

CHUBA, PJ ;

LEON, MA ;

BANERJEE, A ;

PALCHAUDHURI, S .

MOLECULAR & GENERAL GENETICS, 1989, 216 (2-3) :287-292

[4] REGULATORY CASCADE CONTROLS VIRULENCE IN VIBRIO-CHOLERAE [J].

DIRITA, VJ ;

PARSOT, C ;

JANDER, G ;

MEKALANOS, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (12) :5403-5407

[5] NUCLEOTIDE-SEQUENCE OF THE STRUCTURAL GENE, TCPA, FOR A MAJOR PILIN SUBUNIT OF VIBRIO-CHOLERAE [J].

FAAST, R ;

OGIERMAN, MA ;

STROEHER, UH ;

MANNING, PA .

GENE, 1989, 85 (01) :227-231

[6] MOLECULAR-CLONING AND EXPRESSION IN ESCHERICHIA-COLI K-12 OF THE GENE FOR A HEMAGGLUTININ FROM VIBRIO-CHOLERAE [J].

FRANZON, VL ;

MANNING, PA .

INFECTION AND IMMUNITY, 1986, 52 (01) :279-284

[7] STUDIES ON TRANSFORMATION OF ESCHERICHIA-COLI WITH PLASMIDS [J].

HANAHAN, D .

JOURNAL OF MOLECULAR BIOLOGY, 1983, 166 (04) :557-580

[8] TOXIN, TOXIN-COREGULATED PILI, AND THE TOXR REGULON ARE ESSENTIAL FOR VIBRIO-CHOLERAE PATHOGENESIS IN HUMANS [J].

HERRINGTON, DA ;

HALL, RH ;

LOSONSKY, G ;

MEKALANOS, JJ ;

TAYLOR, RK ;

LEVINE, MM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (04) :1487-1492

[9] CLUSTAL - A PACKAGE FOR PERFORMING MULTIPLE SEQUENCE ALIGNMENT ON A MICROCOMPUTER [J].

HIGGINS, DG ;

SHARP, PM .

GENE, 1988, 73 (01) :237-244

[10] SURFACE EXCLUSION GENE-TRAS AND GENE-TRAT OF THE F-SEX FACTOR OF ESCHERICHIA-COLI-K-12 - DETERMINATION OF THE NUCLEOTIDE-SEQUENCE AND PROMOTER AND TERMINATOR ACTIVITIES [J].

JALAJAKUMARI, MB ;

GUIDOLIN, A ;

BUHK, HJ ;

MANNING, PA ;

HAM, LM ;

HODGSON, ALM ;

CHEAH, KC ;

SKURRAY, RA .

JOURNAL OF MOLECULAR BIOLOGY, 1987, 198 (01) :1-11

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