TCP PILUS BIOSYNTHESIS IN VIBRIO-CHOLERAE O1 - GENE SEQUENCE OF TCPC ENCODING AN OUTER-MEMBRANE LIPOPROTEIN

被引：18

作者：

OGIERMAN, MA ^{[1
]}

MANNING, PA ^{[1
]}

机构：

[1] UNIV ADELAIDE, DEPT MICROBIOL & IMMUNOL, ADELAIDE, SA 5001, AUSTRALIA

来源：

FEMS MICROBIOLOGY LETTERS | 1992年 / 97卷 / 1-2期

关键词：

COLONIZATION; ADHERENCE; FIMBRIAE; VIBRIO-CHOLERAE;

D O I：

10.1016/0378-1097(92)90383-Y

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nucleotide sequence of the tcpC gene has been determined. It encodes a 53995-Da protein precursor with a signal sequence and cleavage site typical of a number of outer membrane lipoproteins, which are cleaved by the equivalent of signal peptidase II (Lsp) of Escherichia coli. The location of the tcpC gene is such that it is predicted to be translationally coupled to the 5' and 3' flanking genes, tcpY and tcpD, respectively, indicating that it forms part of an operon. Together with the lipoprotein signal sequence and the several hydrophobic domains it seems likely that TcpC is a surface-anchored trans-outer membrane lipoprotein.

引用

页码：179 / 184

页数：6

共 29 条

[11] PROCESSING OF TCP PILIN BY TCPJ TYPIFIES A COMMON STEP INTRINSIC TO A NEWLY RECOGNIZED PATHWAY OF EXTRACELLULAR PROTEIN SECRETION BY GRAM-NEGATIVE BACTERIA [J].

KAUFMAN, MR ;

SEYER, JM ;

TAYLOR, RK .

GENES & DEVELOPMENT, 1991, 5 (10) :1834-1846

[12] A SIMPLE METHOD FOR DISPLAYING THE HYDROPATHIC CHARACTER OF A PROTEIN [J].

KYTE, J ;

DOOLITTLE, RF .

JOURNAL OF MOLECULAR BIOLOGY, 1982, 157 (01) :105-132

[13] INVOLVEMENT OF CELL-ENVELOPE COMPONENTS IN THE PATHOGENESIS OF VIBRIO-CHOLERAE - TARGETS FOR CHOLERA VACCINE DEVELOPMENT [J].

MANNING, PA .

VACCINE, 1987, 5 (02) :83-87

[14] TNPHOA - A TRANSPOSON PROBE FOR PROTEIN EXPORT SIGNALS [J].

MANOIL, C ;

BECKWITH, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (23) :8129-8133

[15] CHOLERA-TOXIN TRANSCRIPTIONAL ACTIVATOR TOXR IS A TRANSMEMBRANE DNA-BINDING PROTEIN [J].

MILLER, VL ;

TAYLOR, RK ;

MEKALANOS, JJ .

CELL, 1987, 48 (02) :271-279

[16] HOMOLOGY OF TCPN, A PUTATIVE REGULATORY PROTEIN OF VIBRIO-CHOLERAE, TO THE ARAC FAMILY OF TRANSCRIPTIONAL ACTIVATORS [J].

OGIERMAN, MA ;

MANNING, PA .

GENE, 1992, 116 (01) :93-97

[17] TOXR REGULATES THE PRODUCTION OF LIPOPROTEINS AND THE EXPRESSION OF SERUM RESISTANCE IN VIBRIO-CHOLERAE [J].

PARSOT, C ;

TAXMAN, E ;

MEKALANOS, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (05) :1641-1645

[18] DETERMINANTS OF IMMUNOGENICITY AND MECHANISMS OF PROTECTION BY VIRULENT AND MUTANT VIBRIO-CHOLERAE O1 IN RABBITS [J].

PIERCE, NF ;

CRAY, WC ;

KAPER, JB ;

MEKALANOS, JJ .

INFECTION AND IMMUNITY, 1988, 56 (01) :142-148

[19] A WORKBENCH FOR MULTIPLE ALIGNMENT CONSTRUCTION AND ANALYSIS [J].

SCHULER, GD ;

ALTSCHUL, SF ;

LIPMAN, DJ .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1991, 9 (03) :180-190

[20] SIGNIFICANCE OF TOXIN-COREGULATED PILI AS PROTECTIVE ANTIGENS OF VIBRIO-CHOLERAE IN THE INFANT MOUSE MODEL [J].

SHARMA, DP ;

THOMAS, C ;

HALL, RH ;

LEVINE, MM ;

ATTRIDGE, SR .

VACCINE, 1989, 7 (05) :451-456

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