NEW IMMUNOSUPPRESSIVE AGENTS FOR PEDIATRIC TRANSPLANTATION

被引：5

作者：

FERRARESSO, M ^{[1
]}

KAHAN, BD ^{[1
]}

机构：

[1] UNIV TEXAS,SCH MED,DEPT SURG,DIV IMMUNOL & ORGAN TRANSPLANTAT,6431 FANNIN,MSB 6 240,HOUSTON,TX 77030

来源：

PEDIATRIC NEPHROLOGY | 1993年 / 7卷 / 05期

关键词：

IMMUNOSUPPRESSIVE AGENTS; TRANSPLANTATION; CYCLOSPORINE;

D O I：

10.1007/BF00852552

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Pediatric transplantation has always been challenging for transplant surgeons. Although the higher immunoreactivity and the faster metabolism showed by this unique population when compared with adults requires a heavy immunosuppressive regimen, the possibility of disrupting the delicate balance of correct psychophysical development calls for a regimen of more selective and less toxic immunosuppressive drugs. In the past decade several new drugs have been investigated and some of them appear to be very promising, although pleiotropic toxicities have not yet been eliminated. An appropriate pharmacokinetic approach and the evaluation of synergistic multi-drug combinations by rigorous mathematical models would lead to highly selective immunosuppressive regimens which may result in virtually no toxicity.

引用

页码：567 / 573

页数：7

共 80 条

[31]

Berenbaum M.C., Brown, Dose-response relationships for agents inhibiting the immune response, Immunology, 7, pp. 65-71, (1966)

[32]

Frish A.W., Davies G.H., Inhibition of hemagglutinin synthesis by cytoxan, Cancer Res, 25, pp. 745-751, (1965)

[33]

Hurd E.R., The effect of cyclophosphamide treatment on B and T lymphocytes in patient with connective tissue disease, Arthritis Rheum, 16, pp. 554-558, (1973)

[34]

Clements P., Levy J., Barnett E.V., Immunosuppressive effects on B lymphocytes in rheumatoid arthritis, Rheum, 16, pp. 537-541, (1978)

[35]

Fox M., Suppression of tissue immunity by cyclophosphamide, Transplantation, 2, pp. 465-486, (1964)

[36]

Starzl T.E., Halgrion C.G., Penn I., Martineau G., Schroter G., Amemiya H., Putnam C.W., Groth C.G., Cyclophosphamide and human organ transplantation, Lancet, 2, pp. 70-74, (1971)

[37]

Zinke H., Woods J.E., Donor pretreatment in cadaver renal transplantation, Surg Gynecol Obstet, 145, pp. 183-188, (1977)

[38]

Guttmann R.D., Beaudoin J.G., Morehouse D.D., Klassen J., Knaack J., Jeffrey J., Chassot P.G., Abbou C.C., Donor pretreatment as an adjunct to cadaver renal allotransplantation, Transplant Proc, 7, pp. 117-121, (1977)

[39]

Metchinkoff E., Etúde sur la resorption des cellules, Ann Inst Pastcur, 13, pp. 737-769, (1899)

[40]

Kung P.C., Goldstein G., Reinhertz E.L., Schlossman S.F., Monoclonal antibodies defining distinctive human T-cell surface antigens, Science, 206, pp. 347-349, (1979)

← 1 2 3 4 5 6 7 8 →