PREPROGALANIN MESSENGER-RNA IS INCREASED IN VAGAL MOTOR NEURONS FOLLOWING AXOTOMY

被引：34

作者：

RUTHERFURD, SD ^{[1
]}

WIDDOP, RE ^{[1
]}

LOUIS, WJ ^{[1
]}

GUNDLACH, AL ^{[1
]}

机构：

[1] UNIV MELBOURNE,AUSTIN HOSP,DEPT MED,CLIN PHARMACOL & THERAPEUT UNIT,HEIDELBERG,VIC 3084,AUSTRALIA

来源：

MOLECULAR BRAIN RESEARCH | 1992年 / 14卷 / 03期

基金：

英国医学研究理事会;

关键词：

GALANIN; TYROSINE HYDROXYLASE; GENE EXPRESSION; INSITU HYBRIDIZATION; NEURONAL PLASTICITY; NODOSE GANGLIONECTOMY; DORSAL MOTOR NUCLEUS OF THE VAGUS; NUCLEUS AMBIGUUS;

D O I：

10.1016/0169-328X(92)90181-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expression of preprogalanin and tyrosine hydroxylase mRNA was examined in the rat dorsal vagal complex following nodose ganglionectomy and cervical vagotomy, using in situ hybridization of specific S-35-labelled oligonucleotides. Seven days after unilateral cervical vagotomy (and nodose ganglionectomy), neurons in the ipsilateral dorsal motor nucleus of the vagus and nucleus ambiguus expressed 6- to 10-fold increased levels of preprogalanin mRNA. In contrast, tyrosine hydroxylase mRNA was no longer expressed by cells of the dorsal motor nucleus of the vagus after the lesion. These results demonstrate that changes in the expression of the galanin and tyrosine hydroxylase genes occur in vagal motor neurons following lesion of their axons. More generally, these results, and those from other laboratories, demonstrate that specific alterations of neuropeptide and neurotransmitter production, are part of the reactive process activated by nerve injury.

引用

页码：261 / 266

页数：6

共 41 条

[21] SELECTIVE EXPRESSION OF JUN PROTEINS FOLLOWING AXOTOMY AND AXONAL-TRANSPORT BLOCK IN PERIPHERAL-NERVES IN THE RAT - EVIDENCE FOR A ROLE IN THE REGENERATION PROCESS [J].