ENANTIOSELECTIVE PROTONATION OF SAMARIUM ENOLATES BY A C-2-SYMMETRICAL CHIRAL DIOL

被引：36

作者：

TAKEUCHI, S

OHIRA, A

MIYOSHI, N

MASHIO, H

OHGO, Y

机构：

[1] Niigata College of Pharmacy, Niigata, 950-21

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 09期

关键词：

D O I：

10.1016/0957-4166(94)80086-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

High enantioselectivity (up to 97%ee) have been achieved in the protonation of samarium enolates which were generated by SmI2-mediated cross-coupling reaction between unsymmtrical dialkylketene and allyl iodide, using a C-2-symmetric chiral diol as a proton source. The stereochemistry of enolate formation and of the enantioselective protonation is discussed.

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页码：1763 / 1780

页数：18

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