ASYMMETRIC-SYNTHESIS OF BICYCLO[4.3.0]NONAN-8-ONES BY INTRAMOLECULAR PAUSON-KHAND REACTION

被引：44

作者：

CASTRO, J

MOYANO, A

PERICAS, MA

RIERA, A

GREENE, AE

机构：

[1] UNIV BARCELONA,DEPT QUIM ORGAN,MARTI FRANQUES 1-11,E-08028 BARCELONA,SPAIN

[2] UNIV J FOURIER,LEDSS,F-38041 GRENOBLE,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(00)86192-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The intramolecular Pauson-Khand reaction of (E)-1-alkoxy-1-octen-7-ynes derived from (1S,2R)-2-phenylcyclohexanol is described. 7-Alkoxybicyclo[4.3.0]non-1(9)-en-8-ones are obtained in yields up to 65% and with diastereoselectivities higher than 10:1. The absolute configuration of the major diastereomer obtained has been ascertained and can be rationalized on the basis of the preferential conformation of the precursor.

引用

页码：307 / 310

页数：4

共 35 条

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