Determination of fosinopril in pharmaceutical formulations containing hydrochlorothiazide by multiwavelength UV spectrophotometry

被引：29

作者：

Magri, AL

Fabrizio, BB

Magri, AD

Marini, D

机构：

[1] UNIV PERUGIA,IST MERCEOL,PERUGIA,ITALY

[2] LAB CHIM DOGANE & IIII,ROME,ITALY

来源：

TALANTA | 1995年 / 42卷 / 11期

关键词：

fosinopril; hydrochlorothiazide; UV-spectrophotometry;

D O I：

10.1016/0039-9140(95)01642-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive, simple, rapid and precise method for the simultaneous determination of fosinopril (FOS) and hydrochlorothiazide (HCT) in pharmaceutical formulations is presented. These active ingredients are extracted in aqueous solution and measured by multiwavelength UV spectrophotometry using the program QUEST. HCT acts as an internal standard to verify the accuracy of the analysis. Some aspects of the chemical, spectroscopic and thermoanalytical behaviour of FOS are also reported.

引用

页码：1719 / 1723

页数：5

共 8 条

[1] DESIGN OF POTENT COMPETITIVE INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME - CARBOXYALKANOYL AND MERCAPTOALKANOYL AMINO-ACIDS [J].