SEQUENCE-SPECIFIC OLIGONUCLEOTIDE TYPING IN SHONA PATIENTS WITH RHEUMATOID-ARTHRITIS AND HEALTHY CONTROLS FROM ZIMBABWE

被引：21

作者：

CUTBUSH, S

CHIKANZA, IC

BIRO, PA

BEKKER, C

STEIN, M

LUTALO, S

GARCIAPACHECO, JM

MCCLOSKEY, DS

LANCHBURY, JS

SACHS, JA

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DIV MED,RHEUMATOL UNIT,LONDON,ENGLAND

[2] MED SCH HARARE,HARARE,ZIMBABWE

来源：

TISSUE ANTIGENS | 1993年 / 41卷 / 04期

关键词：

RA; SSOS; SHONA;

D O I：

10.1111/j.1399-0039.1993.tb01997.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Seventy-two patients with rheumatoid arthritis (RA) and 82 controls have been typed with the XI Histocompatibility Workshop DRB1 and DQB1 sequence-specific oligonucleotide probes. The increase of DRB1*04 corresponds to an increase of the serologically defined DR4, previously found in a small group of Zimbabwean RA patients and we now show that this increase is due to the subtype DRB1*0405 in association with DQB1*0302. In addition there is a clearcut increase of DRB1*1001 equivalent to the serologically defined DR10. There was no increase amongst RA patients of DRB1*0102 which was the predominant DR1 sub-type amongst controls. In the course of our investigation, we observed a DRB1*04 variant which corresponds to DRB1*0412, newly defined in the XIth Histocompatibility Workshop.

引用

页码：169 / 172

页数：4

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