1,3-BISBIPHENYLYL AND 1,5-BISBIPHENYLYL SUBSTITUTED 3-MERCAPTOTRIAZOLES AS ANGIOTENSIN-II RECEPTOR ANTAGONISTS

被引：6

作者：

BANDURCO, VT ^{[1
]}

MURRAY, WV ^{[1
]}

GILL, A ^{[1
]}

ADDO, M ^{[1
]}

LEWIS, J ^{[1
]}

WACHTER, MP ^{[1
]}

HADDEN, S ^{[1
]}

UNDERWOOD, DC ^{[1
]}

CHEUNG, WM ^{[1
]}

机构：

[1] RW JOHNSON PHARMACEUT RES INST,POB 300,ROUTE 202,RARITAN,NJ 08869

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80915-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of substituted bisbiphenylyl-3-mercaptotriazoles has been been discovered to be potent antagonists of angiotensin II. These compounds were tested in rabbit aortic rings and in a high renin rat model. The best of these compounds have pA2 values > 8.0 and iv activity in the high renin rat at 5 mg/kg.

引用

页码：375 / 379

页数：5

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