THE PROPERDIN STRUCTURAL LOCUS (PFC) LIES CLOSE TO THE LOCUS FOR TISSUE INHIBITOR OF METALLOTHIONINE PROTEASES (TIMP) ON THE MOUSE X-CHROMOSOME

被引：15

作者：

LAVAL, SH

CHEN, ZY

BOYD, Y

机构：

[1] MRC,RADIOBIOL UNIT,DIDCOT OX11 ORD,OXON,ENGLAND

[2] UNIV OXFORD,DEPT BIOCHEM,GENET LAB,OXFORD OX1 3QU,ENGLAND

来源：

GENOMICS | 1991年 / 10卷 / 04期

关键词：

D O I：

10.1016/0888-7543(91)90194-J

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have confirmed the assignment of the structural locus of the complement factor properdin (Pfc) to the mouse X chromosome and mapped it between monoamine oxidase-A (Mao-a) and hypoxanthine phosphoribosyltransferase (Hprt) using a Mus spretus × Mus musculus interspecific backcross of 108 animals. The structural locus for murine tissue inhibitor of metallothionine proteases (Timp) could not be separated from properdin in a panel of 18 recombinant animals. By minimizing the number of double recombinants the following gene order was obtained: Otc-Mao-a-(Pfc, Timp)-Hprt-Cf-9. The implications for comparative mapping of human and mouse X chromosomes are discussed. © 1991.

引用

页码：1030 / 1034

页数：5

共 25 条

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