CAPILLARY ZONE ELECTROPHORESIS STUDY OF NAPHTHYLETHYLCARBAMOYLATED BETA-CYCLODEXTRINS

被引：48

作者：

GAHM, KH

STALCUP, AM

机构：

[1] Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii

来源：

ANALYTICAL CHEMISTRY | 1995年 / 67卷 / 01期

关键词：

D O I：

10.1021/ac00097a005

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Regiospecifically monosubstituted 1-(1-naphthyl)ethylcarbamoylated beta-cyclodextrins (NEC-beta-CDs) were successfully employed as chiral additives in capillary zone electrophoresis (CZE) to achieve chiral separation of N-(3,5-dinitrobenzoyl)phenylglycine (3,5-DNB-PG), phenylalanine (3,5-DNB-PA), and homophenyalanine (3,5-DNB-HPA), The enantioselectivity of the various site-substituted NEC-beta-CDs in CZE was compared with that of native beta-CD. Complexation constants of the three 3,5-DNB amino acids with B-CD were determined from the CZE results: 3,5-DNB-L-HPA, 473 +/- 9 M(-1); 3,5-DNB-D-HPA, 460 +/- 10 M(-1); 3,5-DNB-L-PA, 260 +/- 4 M(-1); 3,5-DNB-D-PA, 161 +/- 3 M(-1); and 3,5-DNB-D,L-PG, 43 +/- 4 M(-1).

引用

页码：19 / 25

页数：7

共 48 条

[1] CHIRAL SEPARATION OF BETA-AMINO ALCOHOLS BY CAPILLARY ELECTROPHORESIS USING CYCLODEXTRINS AS BUFFER ADDITIVES .1. EFFECT OF VARYING OPERATING PARAMETERS [J].