CHROMOSOMAL ASSIGNMENT OF RETINOIC ACID RECEPTOR (RAR) GENES IN THE HUMAN, MOUSE, AND RAT GENOMES

The human genes encoding the α and β forms of the retinoic acid receptor are known to be located on chromosomes 17 (band q21.1: RARA) and 3 (band p24: RARB). By in situ hybridization, we have now localized the gene for retinoic acid receptor γ, RARG, on chromosome 12, band q13. We also mapped the three retinoic acid receptor genes in the mouse, by in situ hybridization, on chromosomes 11, band D (Rar-a); 14, band A (Rar-b); and 15, band F (Rar-g), respectively, and in the rat, using a panel of somatic cell hybrids that segregate rat chromosomes, on chromosomes 10 (RARA), 15 (RARB), and 7 (RARG), respectively. These assignments reveal a retention of tight linkage between RAR and HOX gene clusters. They also establish or confirm and extend the following homologies: (i) between human chromosome 17, mouse chromosome 11, and rat chromosome 10 (RARA); (ii) between human chromosome 3, mouse chromosome 14, and rat chromosome 15 (RARB); and (iii) between human chromosome 12, mouse chromosome 15, and rat chromosome 7 (RARG). © 1991.