CARBON-CARBON BOND FORMATION ON SOLID SUPPORT - SYNTHESIS OF MONOACYL PIPERAZINES BY KNOEVENAGEL-TYPE CONDENSATION-REACTIONS

被引：34

作者：

ZARAGOZA, F

机构：

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 47期

关键词：

D O I：

10.1016/0040-4039(95)01790-O

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Piperazine, linked as carbamate to a Wang resin, could be monoacylated with cyanoacetic acid and 3-oxobutyric acid. The resulting cyanoacetamide underwent Knoevenagel condensations on solid phase at ambient temperature whereas the 3-oxobutyramide did not react under identical reaction conditions.

引用

页码：8677 / 8678

页数：2

共 8 条

[1] ACETOACETYLATION WITH "2,2,6-TRIMETHYL-4H-1,3-DIOXIN-4-ONE - A CONVENIENT ALTERNATIVE TO DIKETENE [J].