Carbohydrate-protein interactions in vascular biology

被引：92

作者：

Nelson, RM

Venot, A

Bevilacqua, MP

Linhardt, RJ

Stamenkovic, I

机构：

[1] UNIV IOWA, COLL PHARM, IOWA CITY, IA 52242 USA

[2] HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, CTR CANC, BOSTON, MA 02129 USA

[3] HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, PATHOL RES CTR, BOSTON, MA 02129 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 1995年 / 11卷

关键词：

cell adhesion; selectins; growth factors; chemokines; endothelial cells; glycosaminoglycans; CD22; CD44;

D O I：

10.1146/annurev.cellbio.11.1.601

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Carbohydrate-protein interactions participate in a wide variety of biological and pathological events. In recent years, particular attention has been paid to the carbohydrate-protein interactions that occur in vascular biology. Sialylated oligosaccharides are ligands of a structurally diverse group of proteins that include the selectins and members of the immunoglobulin superfamily. Various glycosaminoglycans can be recognized by an overlapping set of proteins that include two of the selectins and CD44. Emerging knowledge of carbohydrate-protein interactions in human pathophysiology are discussed.

引用

页码：601 / 631

页数：31

共 185 条

[41] HUMAN PROTEIN-C INHIBITS SELECTIN-MEDIATED CELL-ADHESION - ROLE OF UNIQUE FUCOSYLATED OLIGOSACCHARIDE [J].