INADEQUACY OF CAPTOPRIL CHALLENGE TEST FOR DIAGNOSING RENOVASCULAR HYPERTENSION IN CHILDREN AND ADOLESCENTS

被引：12

作者：

GAUTHIER, B

TRACHTMAN, H

FRANK, R

PILLARI, G

机构：

[1] Long Island Campus of Albert Einstein College of Medicine, Schneider Children's Hospital of Long Island Jewish Medical Center, New Hyde Park, 1042, NY

来源：

PEDIATRIC NEPHROLOGY | 1991年 / 5卷 / 01期

关键词：

HYPERTENSION; RENOVASCULAR DISEASE; CAPTOPRIL;

D O I：

10.1007/BF00852842

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A captopril challenge test (CCT) for renovascular disease in adults was described recently. We used it in 20 consecutive, untreated hypertensive children and adolescents. All had a normal urinalysis and glomerular filtration rate and non-diagnostic renal sonograms or intravenous urograms. Plasma renin activity (PRA) was measured before and 1 h after administration of captopril (0.76 +/- 0.17 mg/kg). The CCT was positive in 10 patients. Renal arteriograms were performed in 7 patients with a positive CCT and in 2 with a negative CCT. Renovascular disease was found in 4 patients, 1 of whom had a negative CCT. The PRA response to captopril was the same in patients with true- and the false-positive tests. The predictive value of the positive test was 43%. In conclusion, we did not find the CCT, as described for adults, to be of value in children and adolescents.

引用

页码：42 / 44

页数：3

共 14 条

[1]

Robson A.M., Special diagnostic studies for the detection of renal and renovascular hypertension, Pediatr Clin North Am, 25, pp. 83-98, (1978)

[2]

Oparil S., Haber E., The renin-angiotensin system, N Engl J Med, 291, pp. 389-401, (1974)

[3]

Majd M., Potter B.M., Guzzetta P.C., Ruley E.J., Captopril enhanced renal scintigraphy for detection of renal artery sternosis — an update, J Nucl Med, 27, (1986)

[4]

Fommei E., Ghione S., Palla L., Mosca F., Ferrari M., Palombo C., Giaconi S., Gazzetti P., Donato L., Renal scintigraphic captopril test in the diagnosis of renovascular hypertension, Hypertension, 10, pp. 212-220, (1987)

[5]

Muller F.B., Sealey J.E., Case D.B., Atlas S.A., Pickering T.G., Pecker, Preibisz J.J., Laragh J.H., The captopril test for identifying renovascular disease in hypertensive patients, Am J Med, 80, pp. 633-644, (1986)

[6]

Report of the Second Task Force on Blood Pressure Control in Children — 1987, Pediatrics, 79, pp. 1-25, (1987)

[7]

Schwartz G.J., Haycock G.B., Edelmann C.M., Spitzer A., A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine, Pediatrics, 58, pp. 259-263, (1976)

[8]

Schwartz G.J., Gauthier B.G., A simple estimate of glomerular filtration rate in adolescent boys, J Pediatr, 106, pp. 522-526, (1985)

[9]

Goldberg S., Krishan I., Hames C.B., Knight M., Spierto F.W., Elevated renin levels in normotensive adolescents, Pediatrics, 54, pp. 596-598, (1974)

[10]

Hiner L.B., Gruskin A.B., Baluarte J., Cote M.L., Plasma renin activity in normal children, J Pediatr, 89, pp. 258-261, (1976)

← 1 2 →