INADEQUACY OF CAPTOPRIL CHALLENGE TEST FOR DIAGNOSING RENOVASCULAR HYPERTENSION IN CHILDREN AND ADOLESCENTS

被引：12

作者：

GAUTHIER, B

TRACHTMAN, H

FRANK, R

PILLARI, G

机构：

[1] Long Island Campus of Albert Einstein College of Medicine, Schneider Children's Hospital of Long Island Jewish Medical Center, New Hyde Park, 1042, NY

来源：

PEDIATRIC NEPHROLOGY | 1991年 / 5卷 / 01期

关键词：

HYPERTENSION; RENOVASCULAR DISEASE; CAPTOPRIL;

D O I：

10.1007/BF00852842

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A captopril challenge test (CCT) for renovascular disease in adults was described recently. We used it in 20 consecutive, untreated hypertensive children and adolescents. All had a normal urinalysis and glomerular filtration rate and non-diagnostic renal sonograms or intravenous urograms. Plasma renin activity (PRA) was measured before and 1 h after administration of captopril (0.76 +/- 0.17 mg/kg). The CCT was positive in 10 patients. Renal arteriograms were performed in 7 patients with a positive CCT and in 2 with a negative CCT. Renovascular disease was found in 4 patients, 1 of whom had a negative CCT. The PRA response to captopril was the same in patients with true- and the false-positive tests. The predictive value of the positive test was 43%. In conclusion, we did not find the CCT, as described for adults, to be of value in children and adolescents.

引用

页码：42 / 44

页数：3

共 14 条

[11]

Stalker H.P., Holland N.H., Kotchen J.M., Kotchen T.A., Plasma renin actiivty in healthy children, J Pediatr, 89, pp. 256-258, (1976)

[12]

Gaul M.K., Linn W.D., Mulrow C.D., Captopril stimulated renin secretion in the diagnosis of renovascular hypertension, Am J Hypertens, 2, pp. 335-340, (1989)

[13]

Gosse P., Dupas J.Y., Reynaud P., Jullien E., Dallocchio M., The captopril test in the detection of renovascular hypertension in a population with low prevalence of the disease. A prospective study, Am J Hypertens, 2, pp. 191-193, (1989)

[14]

Daman Wille C.E., Shah V., Uchiyama M., Dillon M.J., The captopril test: an aid to investigation of hypertension, Arch Dis Child, 64, pp. 229-234, (1989)

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