PROTEIN-KINASE-C ACTIVATION INHIBITS GLUTAMATE-INDUCED CYTOTOXICITY IN A NEURONAL CELL-LINE

被引：310

作者：

DAVIS, JB ^{[1
]}

MAHER, P ^{[1
]}

机构：

[1] SALK INST BIOL RES,LA JOLLA,CA 92037

来源：

BRAIN RESEARCH | 1994年 / 652卷 / 01期

基金：

美国国家卫生研究院;

关键词：

12-O-TETRADECANOYLPHORBOL-13-ACETATE; NEUROTOXICITY; OXIDATIVE STRESS; GLUTATHIONE; ANTIOXIDANT;

D O I：

10.1016/0006-8993(94)90334-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A neuronal cell line, HT-22, is sensitive to glutamate cytotoxicity via a non-receptor mediated oxidative pathway. 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, blocks this glutamate-induced cell death. Down-regulation of protein kinase C eliminates the protection against glutamate cytotoxicity afforded by TPA. The data suggest that protein kinase C activation blocks an early step in the cytotoxic pathway.

引用

页码：169 / 173

页数：5

共 20 条

[11] MIYAMOTO M, 1989, J PHARMACOL EXP THER, V250, P1132
[12] INDUCTION AND EXPRESSION OF LONG-TERM AND SHORT-TERM NEUROSECRETORY POTENTIATION IN A NEURAL CELL-LINE
MORIMOTO, BH
KOSHLAND, DE
[J]. NEURON, 1990, 5 (06) : 875 - 880
[13] IMMATURE CORTICAL-NEURONS ARE UNIQUELY SENSITIVE TO GLUTAMATE TOXICITY BY INHIBITION OF CYSTINE UPTAKE
MURPHY, TH
SCHNAAR, RL
COYLE, JT
[J]. FASEB JOURNAL, 1990, 4 (06) : 1624 - 1633
[14] GLUTAMATE TOXICITY IN A NEURONAL CELL-LINE INVOLVES INHIBITION OF CYSTINE TRANSPORT LEADING TO OXIDATIVE STRESS
MURPHY, TH
MIYAMOTO, M
SASTRE, A
SCHNAAR, RL
COYLE, JT
[J]. NEURON, 1989, 2 (06) : 1547 - 1558
[15] THE MOLECULAR HETEROGENEITY OF PROTEIN KINASE-C AND ITS IMPLICATIONS FOR CELLULAR-REGULATION
NISHIZUKA, Y
[J]. NATURE, 1988, 334 (6184) : 661 - 665
[16] OKA A, 1993, J NEUROSCI, V13, P1441
[17] RICE GC, 1986, CANCER RES, V46, P6105
[18] SCHABERT D, 1992, P NATL ACAD SCI USA, V89, P8264
[19] EXCESS K+ AND PHORBOL ESTER ACTIVATE PROTEIN KINASE-C AND SUPPORT THE SURVIVAL OF CHICK SYMPATHETIC NEURONS IN CULTURE
WAKADE, AR
WAKADE, TD
MALHOTRA, RK
BHAVE, SV
[J]. JOURNAL OF NEUROCHEMISTRY, 1988, 51 (03) : 975 - 983
[20] THE PROTEIN-KINASE INHIBITOR STAUROSPORINE, LIKE PHORBOL ESTERS, INDUCES THE ASSOCIATION OF PROTEIN KINASE-C WITH MEMBRANES
WOLF, M
BAGGIOLINI, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 154 (03) : 1273 - 1279

← 1 2 →