Total synthesis of (+)-pyripyropene A. A potent, orally bioavailable inhibitor of acyl-CoA:cholesterol acyltransferase

被引:72
作者
Nagamitsu, T
Sunazuka, T
Obata, R
Tomoda, H
Tanaka, H
Harigaya, Y
Omura, S
Smith, AB
机构
[1] UNIV PENN,MONELL CHEM SENSES CTR,DEPT CHEM,PHILADELPHIA,PA 19104
[2] UNIV PENN,RES STRUCT MATTER LAB,PHILADELPHIA,PA 19104
[3] KITASATO UNIV,KITASATO INST,BIOL FUNCT RES CTR,MINATO KU,TOKYO 108,JAPAN
[4] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN
关键词
D O I
10.1021/jo00130a005
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:8126 / 8127
页数:2
相关论文
共 30 条
[1]  
BELL FP, 1986, PHARM CONTROL HYPERL, P409
[2]  
BILHEIMER JT, 1991, 9TH INT S ATH ROS, P94
[3]   PALLADIUM-CATALYZED CARBONYLATION OF ENOL TRIFLATES - A NOVEL METHOD FOR ONE-CARBON HOMOLOGATION OF KETONES TO ALPHA,BETA-UNSATURATED CARBOXYLIC-ACID DERIVATIVES [J].
CACCHI, S ;
MORERA, E ;
ORTAR, G .
TETRAHEDRON LETTERS, 1985, 26 (08) :1109-1112
[4]  
CHANG G, 1993, 206TH NAT M AM CHEM, P337
[5]   PYRONE STUDIES . LINEAR ALPHA-PYRONE ROUTE TO PROTECTED BETA-POLYKETONES [J].
DOUGLAS, JL ;
MONEY, T .
CANADIAN JOURNAL OF CHEMISTRY, 1968, 46 (05) :695-&
[6]   THE DIRECTED REDUCTION OF BETA-HYDROXY KETONES EMPLOYING ME4NHB(OAC)3 [J].
EVANS, DA ;
CHAPMAN, KT .
TETRAHEDRON LETTERS, 1986, 27 (49) :5939-5942
[7]  
FURLENMEIER A., 1966, HELV CHIM ACTA, V49, P1591, DOI 10.1002/hlca.19660490518
[8]  
HEIDER JG, 1986, PHARM CONTROL HYPERL, P423
[9]   SYNTHESIS OF (+/-)-11-NOR-9-CARBOXY-DELTA-9-TETRAHYDROCANNABINOL - NEW SYNTHETIC APPROACHES TO CANNABINOIDS [J].
HUFFMAN, JW ;
ZHANG, XH ;
WU, MJ ;
JOYNER, HH ;
PENNINGTON, WT .
JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (04) :1481-1489
[10]   GERI-BP001, A NEW INHIBITOR OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY ASPERGILLUS-FUMIGATUS F37 [J].
JEONG, TS ;
KIM, SU ;
KWON, BM ;
SON, KH ;
KIM, YK ;
CHOI, MU ;
BOK, SH .
TETRAHEDRON LETTERS, 1994, 35 (21) :3569-3570