USE OF PHYSICOCHEMICAL PARAMETERS IN DISTANCE GEOMETRY AND RELATED 3-DIMENSIONAL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS - A DEMONSTRATION USING ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE INHIBITORS

被引：66

作者：

GHOSE, AK ^{[1
]}

CRIPPEN, GM ^{[1
]}

机构：

[1] TEXAS A&M UNIV,DEPT CHEM,COLLEGE STN,TX 77843

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 03期

关键词：

D O I：

10.1021/jm00381a013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：333 / 346

页数：14

共 29 条

[1] DIFFERENTIAL BINDING TO HYDROPHOBIC BONDING REGION OF T2 PHAGE INDUCED ESCHERICHIA COLI B AND PIGEON LIVER DIHYDROFOLIC REDUCTASES
BAKER, BR
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (05) : 912 - &
[2] THE BINDING OF TRIMETHOPRIM TO BACTERIAL DIHYDROFOLATE-REDUCTASE
BAKER, DJ
BEDDELL, CR
CHAMPNESS, JN
GOODFORD, PJ
NORRINGTON, FEA
SMITH, DR
STAMMERS, DK
[J]. FEBS LETTERS, 1981, 126 (01) : 49 - 52
[3] TRIMETHOPRIM BINDING TO BACTERIAL AND MAMMALIAN DIHYDROFOLATE-REDUCTASE - A COMPARISON BY PROTON AND C-13 NUCLEAR MAGNETIC-RESONANCE
BIRDSALL, B
ROBERTS, GCK
FEENEY, J
DANN, JG
BURGEN, ASV
[J]. BIOCHEMISTRY, 1983, 22 (24) : 5597 - 5604
[4] BOLIN JT, 1982, J BIOL CHEM, V257, P13650
[5] BROTO P, 1984, EUR J MED CHEM, V19, P71
[6] DISTANCE GEOMETRY APPROACH TO RATIONALIZING BINDING DATA
CRIPPEN, GM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (08) : 988 - 997
[7] FILMAN DJ, 1982, J BIOL CHEM, V257, P13663
[8] GENERAL DISTANCE GEOMETRY 3-DIMENSIONAL RECEPTOR MODEL FOR DIVERSE DIHYDROFOLATE-REDUCTASE INHIBITORS
GHOSE, AK
CRIPPEN, GM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (07) : 901 - 914
[9] COMBINED DISTANCE GEOMETRY ANALYSIS OF DIHYDROFOLATE-REDUCTASE INHIBITION BY QUINAZOLINES AND TRIAZINES
GHOSE, AK
CRIPPEN, GM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (07) : 996 - 1010
[10] QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP BY DISTANCE GEOMETRY - QUINAZOLINES AS DIHYDROFOLATE-REDUCTASE INHIBITORS
GHOSE, AK
CRIPPEN, GM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (08) : 892 - 899

← 1 2 3 →