EFFECTS OF K+ CHANNEL OPENERS ON THE VASCULAR ACTIONS OF HUMAN GAMMA-GLOBULIN

被引：2

作者：

ABRAHAMS, Z ^{[1
]}

SUTTER, MC ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT,VANCOUVER V6T 1Z3,BC,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 252卷 / 02期

关键词：

K+ ACTIVATOR/OPENER; K+ CHANNEL INACTIVATOR/CLOSER; GAMMA GLOBULIN; HUMAN; MESENTERIC PORTAL VEIN;

D O I：

10.1016/0014-2999(94)90597-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to determine if the stimulatory action of human gamma globulin on the spontaneous activity of the rat mesenteric portal vein is due to decreased K+ conductance. Glibenclamide potentiated the action of human gamma-globulin on the portal vein by 45% and on its own had a concentration- and time-dependent biphasic (increase followed by a decrease) effect on the spontaneous activity of the portal vein. Diazoxide and pinacidil both inhibited the action of human gamma-globulin on the rat mesenteric portal vein. Levcromakalim (BRL 38227) potentiated the stimulatory action of human gamma-globulin on the integrated force of the spontaneous contractions of the rat mesenteric portal vein by 40% and 49% at concentrations of 0.5 and 5 mu M, respectively. These studies suggest that human gamma-globulin can act by directly modulating a K+ channel.

引用

页码：195 / 203

页数：9

共 48 条

[11] STRUCTURE-ACTIVITY-RELATIONSHIPS OF K+ CHANNEL OPENERS [J].

EDWARDS, G ;

WESTON, AH .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (10) :417-422

[12] GLIBENCLAMIDE IS A COMPETITIVE ANTAGONIST OF CROMAKALIM, PINACIDIL AND RP-49356 IN GUINEA-PIG PULMONARY-ARTERY [J].

ELTZE, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 165 (2-3) :231-239

[13] POTASSIUM CHANNEL OPENERS ACT THROUGH AN ACTIVATION OF ATP-SENSITIVE K+ CHANNELS IN GUINEA-PIG CARDIAC MYOCYTES [J].

ESCANDE, D ;

THURINGER, D ;

LEGUERN, S ;

COURTEIX, J ;

LAVILLE, M ;

CAVERO, I .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1989, 414 (06) :669-675

[14] ELECTROPHYSIOLOGICAL EVIDENCE FOR THE INHIBITION OF POTASSIUM PERMEABILITY IN PANCREATIC BETA-CELLS BY GLIBENCLAMIDE [J].

FERRER, R ;

ATWATER, I ;

OMER, EM ;

GONCALVES, AA ;

CROGHAN, PC ;

ROJAS, E .

QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 1984, 69 (04) :831-839

[15]

FOSSET M, 1988, J BIOL CHEM, V263, P7933

[16] ACTIONS OF 4-AMINOPYRIDINE ON VASCULAR SMOOTH-MUSCLE TISSUES OF THE GUINEA-PIG [J].

HARA, Y ;

KITAMURA, K ;

KURIYAMA, H .

BRITISH JOURNAL OF PHARMACOLOGY, 1980, 68 (01) :99-106

[17] MECHANISM OF ACTION AND SYSTEMIC AND REGIONAL HEMODYNAMICS OF THE POTASSIUM CHANNEL ACTIVATOR BRL34915 AND ITS ENANTIOMERS [J].

HOF, RP ;

QUAST, U ;

COOK, NS ;

BLARER, S .

CIRCULATION RESEARCH, 1988, 62 (04) :679-686

[18]

HU SL, 1990, J PHARMACOL EXP THER, V253, P771

[19] CLINICAL-PHARMACOLOGY OF SULFONYLUREA HYPOGLYCEMIC AGENTS .1. [J].

JACKSON, JE ;

BRESSLER, R .

DRUGS, 1981, 22 (03) :211-245

[20]

KAJIOKA S, 1990, J PHARMACOL EXP THER, V254, P905

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