A GENETIC-LINKAGE MAP FOR THE ZEBRAFISH

被引：331

作者：

POSTLETHWAIT, JH ^{[1
]}

JOHNSON, SL ^{[1
]}

MIDSON, CN ^{[1
]}

TALBOT, WS ^{[1
]}

GATES, M ^{[1
]}

BALLINGER, EW ^{[1
]}

AFRICA, D ^{[1
]}

ANDREWS, R ^{[1
]}

CARL, T ^{[1
]}

EISEN, JS ^{[1
]}

HORNE, S ^{[1
]}

KIMMEL, CB ^{[1
]}

HUTCHINSON, M ^{[1
]}

JOHNSON, M ^{[1
]}

RODRIGUEZ, A ^{[1
]}

机构：

[1] UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403

来源：

SCIENCE | 1994年 / 264卷 / 5159期

关键词：

D O I：

10.1126/science.8171321

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To facilitate molecular genetic analysis of vertebrate development, haploid genetics was used to construct a recombination map for the zebrafish Danio (Brachydanio) rerio. The map consists of 401 random amplified polymorphic DNAs (RAPDs) and 13 simple sequence repeats spaced at an average interval of 5.8 centimorgans. Strategies that exploit the advantages of haploid genetics and RAPD markers were developed that quickly mapped lethal and Visible mutations and that placed cloned genes on the map. This map is useful for the position-based cloning of mutant genes, the characterization of chromosome rearrangements, and the investigation of evolution in vertebrate genomes.

引用

页码：699 / 703

页数：5

共 58 条

[1]

AKIMENKO MA, UNPUB

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ALJANABI SM, 1993, GENETICS, V134, P1249

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