GLUCOSE ENHANCEMENT OF MEMORY IN ELDERLY HUMANS - AN INVERTED-U DOSE-RESPONSE CURVE

被引：143

作者：

PARSONS, MW ^{[1
]}

GOLD, PE ^{[1
]}

机构：

[1] UNIV VIRGINIA,DEPT PSYCHOL,LIFE SCI LABS,GILMER HALL,CHARLOTTESVILLE,VA 22903

来源：

NEUROBIOLOGY OF AGING | 1992年 / 13卷 / 03期

关键词：

MEMORY; ENHANCEMENT WITH GLUCOSE; GLUCOSE; EFFECTS ON MEMORY; AGING; GLUCOSE ENHANCEMENT OF MEMORY;

D O I：

10.1016/0197-4580(92)90114-D

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In animals enhancement of memory with glucose and many other treatments is characterized by an inverted-U dose-response curve. The present experiment examined the dose-response curve for glucose enhancement of memory in elderly humans. Using a repeated measures, counterbalanced, crossover design, the subjects (60-82 year olds) were tested on four sessions, separated by 1 week or more, for performance on the Wechsler Logical Memory Test after ingestion of a fruit drink sweetened with glucose (0, 10, 25, and 50 g) and saccharin matched to comparable taste. The findings indicate that glucose enhanced performance on this test in an inverted-U dose-response manner, with optimal enhancement obtained at the 25 g glucose dose. These findings provide further demonstration of glucose enhancement of memory in elderly humans and also describe an additional analogy between the characteristics of glucose enhancement of memory in animals and humans.

引用

页码：401 / 404

页数：4

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