BIOLOGICAL AND TOXICOLOGICAL CONSEQUENCES OF QUINONE METHIDE FORMATION

被引:150
作者
THOMPSON, DC
THOMPSON, JA
SUGUMARAN, M
MOLDEUS, P
机构
[1] UNIV COLORADO, HLTH SCI CTR, SCH PHARM, MOLEC & ENVIRONM TOXICOL PROGRAM, DENVER, CO 80262 USA
[2] UNIV MASSACHUSETTS, DEPT BIOL, BOSTON, MA 02125 USA
[3] KAROLINSKA INST, DEPT TOXICOL, S-10401 STOCKHOLM 60, SWEDEN
关键词
QUINONE METHIDE; REVIEW; TOXICITY; BIOCHEMISTRY;
D O I
10.1016/0009-2797(93)90117-H
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Quinone methides are a class of reactive, electrophilic compounds which are capable of alkylating cellular macromolecules. They are formed during xenobiotic biotransformation reactions and are hypothesized to mediate the toxicity of a large number of quinone antitumor drugs as well as several alkylphenols. In addition, oxidation of specific endogenous alkylphenols (e.g. coniferyl alcohol) and alkylcatechols (e.g. N-acetyldopamine, dopa) to quinone methides plays an important role in the synthesis of several complex plant and animal polymers, including lignin, cuticle and melanin. The role of quinone methides in these various processes is reviewed.
引用
收藏
页码:129 / 162
页数:34
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