THE CORTICAL NEURITIC DYSTROPHY OF ALZHEIMERS-DISEASE - NATURE, SIGNIFICANCE, AND POSSIBLE PATHOGENESIS

被引：29

作者：

LARNER, AJ ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,ADDENBROOKES HOSP,DEPT NEUROL,CAMBRIDGE,ENGLAND

来源：

DEMENTIA | 1995年 / 6卷 / 04期

基金：

英国惠康基金;

关键词：

ALZHEIMERS DISEASE; CORTICAL NEURITIC DYSTROPHY; GROWTH CONES; DENDRITES; AXONS; SPROUTING; NEURITE GROWTH-PROMOTING FACTORS; NEURITE GROWTH-INHIBITORY FACTORS;

D O I：

10.1159/000106950

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It has been increasingly appreciated in the last decade that the neocortex of the Alzheimer's disease brain is characterized by a widespread neuritic dystrophy, spatially distinct from that observed surrounding neuritic amyloid plaques. The nature and significance of this cortical neuritic dystrophy and its possible pathogenesis are the topics of this review. It may represent a regenerative sprouting response of neurons to partial deafferentation following cell loss; alternatively it may reflect a primary aberrant growth phenomenon leading to cell loss. Such changes could result from derangement of neurite growth-promoting and growth-inhibitory factors in the Alzheimer's disease brain.

引用

页码：218 / 224

页数：7

共 84 条

[41] KOWALL N W, 1989, Neurology, V39, P397
[42] KOWALL NW, 1993, ADV NEUROL, V59, P5
[43] KOWALL NW, 1987, ANN NEUROL, V422, P639
[44] LARNER AJ, IN PRESS SEIZURE
[45] LARNER AJ, IN PRESS BIOL REV
[46] THY-1 IN HIPPOCAMPUS - NORMAL ANATOMY AND NEURITIC GROWTH IN ALZHEIMERS-DISEASE
LEIFER, D
KOWALL, NW
[J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1992, 51 (02) : 133 - 141
[47] INCREASED S100-BETA NEUROTROPHIC ACTIVITY IN ALZHEIMERS-DISEASE TEMPORAL-LOBE
MARSHAK, DR
PESCE, SA
STANLEY, LC
GRIFFIN, WST
[J]. NEUROBIOLOGY OF AGING, 1992, 13 (01) : 1 - 7
[48] PATTERNS OF ABERRANT SPROUTING IN ALZHEIMERS-DISEASE
MASLIAH, E
MALLORY, M
HANSEN, L
ALFORD, M
ALBRIGHT, T
DETERESA, R
TERRY, R
BAUDIER, J
SAITOH, T
[J]. NEURON, 1991, 6 (05) : 729 - 739
[49] MCKEE A C, 1990, Society for Neuroscience Abstracts, V16, P461
[50] DYSTROPHIC NEURITES IN THE NEOCORTEX ARE THE CRITICAL NEUROPATHOLOGICAL CORRELATE OF DEMENTIA IN ALZHEIMERS-DISEASE
MCKEE, AC
KOSIK, KS
KOWALL, NW
[J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1990, 49 (03) : 336 - 336

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