THE MAJOR PERIPHERAL MYELIN PROTEIN ZERO GENE - STRUCTURE AND LOCALIZATION IN THE CLUSTER OF FC-GAMMA RECEPTOR GENES ON HUMAN-CHROMOSOME 1Q21.3-Q23

被引：30

作者：

PHAMDINH, D

FOURBIL, Y

BLANQUET, F

MATTEI, MG

ROECKEL, N

LATOUR, P

CHAZOT, G

VANDENBERGHE, A

DAUTIGNY, A

机构：

[1] UNIV PARIS 06,INST NEUROSCI,EQUIPE ATIPE,CNRS,UNITE 1488,F-75252 PARIS 05,FRANCE

[2] HOP ANTIQUAILLE,NEUROGENET LAB,F-69321 LYON 05,FRANCE

[3] HOP ENFANTS LA TIMONE,INSERM,U242,F-13385 MARSEILLE 05,FRANCE

[4] UNIV LYON 1,FAC PHARM,F-69008 LYON,FRANCE

来源：

HUMAN MOLECULAR GENETICS | 1993年 / 2卷 / 12期

关键词：

D O I：

10.1093/hmg/2.12.2051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have characterized the human gene encoding the major peripheral myelin protein zero (PO) and assigned it, by in situ hybridization, to the q21.3 - q23 region of human chromosome 1. This region is known to contain a cluster of interspersed genes coding for the related human leukocyte receptors of the Fc portion of the immunoglobulin G (Fc gamma RI, II, III). This colocalization was refined by the finding of a yeast artificial chromosome YAC) of the Centre d'Etude du Polymorphisme Humain (CEPH) library, hybridizing to the PO and Fc gamma RIIA genes, demonstrating their physical linkage. These data may have important implications in demyelinating diseases studies like Charcot-Marie-Tooth disease type 1B (CMT1B).

引用

页码：2051 / 2054

页数：4

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