EFFECTS OF FEEDING LIPIDS OF DIFFERENT FATTY-ACID COMPOSITIONS UPON RAT LYMPHOCYTE-PROLIFERATION

被引:22
作者
CALDER, PC [1 ]
COSTAROSA, LFBP [1 ]
CURI, R [1 ]
机构
[1] UNIV SAO PAULO,INST BIOMED SCI,DEPT PHYSIOL & BIOPHYS,BR-05508900 SAO PAULO,BRAZIL
基金
巴西圣保罗研究基金会;
关键词
LIPIDS; FATTY ACIDS; LYMPHOCYTE PROLIFERATION; LOW FAT DIET;
D O I
10.1016/0024-3205(94)00910-4
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Weanling Wistar rats were fed for 8 weeks on a low fat (3% by weight) diet (LF) or on diets containing 15% by weight hydrogenated coconut oil (coconut oil), cocoa butter, cashew kernel oil (cashew oil), canola oil or soya bean oil (soya oil). Each of the high fat diets resulted in inhibition of spleen lymphocyte proliferation in response to concanavalin A (Con A), a T-cell mitogen. Feeding the soya oil diet caused more than 95% inhibition of proliferation, compared with feeding the LF diet. Amongst the high fat diets, feeding the cashew, canola or soya oil diets resulted in inhibition of proliferation compared with feeding the coconut oil diet while feeding the soya oil diet resulted in inhibition of proliferation compared with feeding the cocoa butter or canola oil diets. Proliferation of lymphocytes in response to Con A was also investigated using whole blood culture. Once again, feeding the soya oil diet resulted in a dramatic decrease in proliferation (80%) compared with feeding the LF diet. Feeding the soya oil diet also inhibited proliferation compared with feeding the coconut oil, cocoa butter or cashew oil diets. Feeding the canola oil diet resulted in inhibition of proliferation compared with feeding the LF or cocoa butter diets.
引用
收藏
页码:455 / 463
页数:9
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