ANALYSIS OF MALARIA PIGMENT FROM PLASMODIUM-FALCIPARUM

被引：15

作者：

HEMPELMANN, E ^{[1
]}

MARQUES, HM ^{[1
]}

机构：

[1] UNIV WITWATERSRAND,CTR MOLEC DESIGN,DEPT CHEM,JOHANNESBURG,SOUTH AFRICA

来源：

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS | 1994年 / 32卷 / 01期

关键词：

MALARIA PIGMENT; UV-VIS SPECTRA; HPLC; SDS PAGE;

D O I：

10.1016/1056-8719(94)90013-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The biochemical pathway for the production of malaria pigment (haemozoin) forms a fundamental difference between host and parasite and is likely to be an important drug target. A simple method for the isolation of malaria pigment is described. The resultant product retained the in vivo crystalline appearance of pigment as judged by polarizing microscopy. Conditions were found for the disaggregation and separation of pigment. As malaria pigment can adsorb drugs, haem, and iron, such separation techniques are useful tools for studies on the impairment of haemoglobin digestion and pigment formation by antimalarials.

引用

页码：25 / 30

页数：6