RESISTANCE TO INSULIN-MEDIATED GLUCOSE-UPTAKE AND HYPERINSULINEMIA IN WOMEN WHO HAD PREECLAMPSIA DURING PREGNANCY

被引：72

作者：

FUH, MMT

YIN, CS

PEI, D

SHEU, WHH

JENG, CY

CHEN, YDI

REAVEN, GM

机构：

[1] Division of Endocrinology and Metabolism, Tri-Services General Hospital, National Defense Medical Center, Taipei

[2] Department of Obstetrics and Gynecology, Tri-Services General Hospital, National Defense Medical Center, Taipei

[3] Department of Medicine, Stanford University School of Medicine and Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Palo Alto, CA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1995年 / 8卷 / 07期

关键词：

INSULIN RESISTANCE; HYPERINSULINEMIA; PREECLAMPSIA;

D O I：

10.1016/0895-7061(95)00078-4

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Plasma glucose and insulin responses to a 75-g oral glucose load, and the steady-state plasma insulin (SSPI) and glucose (SSPG) concentrations after an infusion of somatostatin, insulin, and glucose, were determined 2 months after delivery in 26 women; 13 who had a normal pregnancy and 13 who developed preeclampsia. The plasma glucose response to oral glucose was not different in the two groups, but the plasma insulin response was significantly greater (P <.02) in those who had been preeclamptic. Although the mean (+/-SE) SSPI concentrations during the infusion study were similar in the two groups (51 +/- 2 v 56 +/- 2 mu U/mL), the SSPG concentrations were significantly higher (P <.02) in those who developed preeclampsia (160 +/- 17 v 119 +/- 17 mg/dL). Thus, when studied 2 months after delivery, women who developed preeclampsia were relatively insulin resistant and hyperinsulinemic when compared to those who had an uncomplicated pregnancy.

引用

页码：768 / 771

页数：4

共 24 条

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