RESISTANCE TO INSULIN-MEDIATED GLUCOSE-UPTAKE AND HYPERINSULINEMIA IN WOMEN WHO HAD PREECLAMPSIA DURING PREGNANCY

被引：72

作者：

FUH, MMT

YIN, CS

PEI, D

SHEU, WHH

JENG, CY

CHEN, YDI

REAVEN, GM

机构：

[1] Division of Endocrinology and Metabolism, Tri-Services General Hospital, National Defense Medical Center, Taipei

[2] Department of Obstetrics and Gynecology, Tri-Services General Hospital, National Defense Medical Center, Taipei

[3] Department of Medicine, Stanford University School of Medicine and Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Palo Alto, CA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1995年 / 8卷 / 07期

关键词：

INSULIN RESISTANCE; HYPERINSULINEMIA; PREECLAMPSIA;

D O I：

10.1016/0895-7061(95)00078-4

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Plasma glucose and insulin responses to a 75-g oral glucose load, and the steady-state plasma insulin (SSPI) and glucose (SSPG) concentrations after an infusion of somatostatin, insulin, and glucose, were determined 2 months after delivery in 26 women; 13 who had a normal pregnancy and 13 who developed preeclampsia. The plasma glucose response to oral glucose was not different in the two groups, but the plasma insulin response was significantly greater (P <.02) in those who had been preeclamptic. Although the mean (+/-SE) SSPI concentrations during the infusion study were similar in the two groups (51 +/- 2 v 56 +/- 2 mu U/mL), the SSPG concentrations were significantly higher (P <.02) in those who developed preeclampsia (160 +/- 17 v 119 +/- 17 mg/dL). Thus, when studied 2 months after delivery, women who developed preeclampsia were relatively insulin resistant and hyperinsulinemic when compared to those who had an uncomplicated pregnancy.

引用

页码：768 / 771

页数：4

共 24 条

[11]

Sowers J.R., Standley P.R., Jacober S., Et al., Postpartum abnormalities of carbohydrate and cellular calcium metabolism in pregnancy induced hypertension, Am J Hypertens, 6, pp. 302-307, (1993)

[12]

Bauman W.A., Maimen M., Langer O., An association between hyperinsulinemia and hypertension during the third trimester of pregnancy, Am J Obstet Gynecol, 159, pp. 446-450, (1988)

[13]

Solomon C.G., Graves S.W., Greene M.F., Seely E.W., Glucose intolerance as a predictor of hypertension in pregnancy, Hypertension, 23, pp. 717-721, (1994)

[14]

Management of Preeclampsia, (1986)

[15]

Kadish A.H., Litle R.L., Stenberg J.C., A new and rapid method for the determination of glucose by rate of oxygen consumption, Clin Chem, 14, pp. 116-131, (1971)

[16]

Hales C.N., Randle P.J., Immunoassay of insulin with insulin antibody precipitate, Biochem J, 88, pp. 137-146, (1963)

[17]

Jacober S.J., Morris D.A., Sowers J.R., Postpartum blood pressure and insulin sensitivity in African-American women with recent preeclampsia, Am J Hypertens, 7, pp. 933-936, (1994)

[18]

Bottoms S.F., Niyogi T.G., Standley P.R., Et al., Insulin resistance with the development of preeclampsia in urban black women (Abstract), Am J Hypertens, 5, (1992)

[19]

Marigliano A., Tedde R., Sechi L.A., Et al., Insulinemia and blood pressure relationships in patients with primary and secondary hypertension, and with or without glucose metabolism impairment, Am J Hypertens, 3, pp. 521-526, (1990)

[20]

Shamiss A., Carroll J., Rosenthal T., Insulin resistance in secondary hypertension, Am J Hypertens, 5, pp. 26-28, (1992)

← 1 2 3 →