EVIDENCE FOR THE PRESENCE OF 5-HT(1B) RECEPTOR MESSENGER-RNA IN NEURONS OF THE RAT TRIGEMINAL GANGLIA

被引：48

作者：

BRUINVELS, AT

LANDWEHRMEYER, B

MOSKOWITZ, MA

HOYER, D

机构：

[1] SANDOZ PHARMA LTD,PRECLIN RES 360-604,CH-4002 BASEL,SWITZERLAND

[2] KANTONSPITAL,DEPT NEUROPATHOL,CH-4002 BASEL,SWITZERLAND

[3] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,STROKE RES LAB,BOSTON,MA 02114

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 227卷 / 03期

关键词：

TRIGEMINAL GANGLIA (RAT); 5-HT(1B) RECEPTOR MESSENGER RNA; 5-HT(1B) RECEPTOR BINDING SITES;

D O I：

10.1016/0922-4106(92)90017-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In situ hybridization histochemistry and receptor autoradiography were used to determine the presence of 5-HT1B receptor messenger RNA (mRNA) and 5-HT1B receptor proteins, respectively, in rat trigeminal ganglia. Receptor autoradiography on rat trigeminal ganglia, using appropriate 5-HT1B radioligands, did not demonstrate any specific labelling. In contrast, in situ hybridization showed that many ganglion cells contain 5-HT1B receptor mRNA, suggesting the presence of presynaptic 5-HT1B receptors on trigeminovascular neurons.

引用

页码：357 / 359

页数：3

共 8 条

[1] DIHYDROERGOTAMINE AND SUMATRIPTAN ATTENUATE LEVELS OF CGRP IN PLASMA IN RAT SUPERIOR SAGITTAL SINUS DURING ELECTRICAL-STIMULATION OF THE TRIGEMINAL GANGLION [J].