CYTOTOXIC ENT-KAURENE DITERPENOIDS FROM 3 ISODON SPECIES

被引：21

作者：

SUN, HD

LIN, ZW

NIU, FD

LIN, LZ

CHAI, HB

PEZZUTO, JM

CORDELL, GA

机构：

[1] UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,PROGRAM COLLABORAT RES PHARMACEUT SCI,CHICAGO,IL 60612

[2] ACAD SINICA,KUNMING INST BOT,PHYTOCHEM LAB,KUNMING 650204,PEOPLES R CHINA

来源：

PHYTOCHEMISTRY | 1995年 / 38卷 / 02期

关键词：

ISODON LOXOTHYRSA; I-PLEIOPHYLLUS; I-ADENOLOMA; LABIATAE; ENT-KAURENE DITERPENOIDS; LOXOTHYRIN A; ADENOLIN B; LONGIKAURIN F; COETSOIDIN G; COETSOIDIN A; COETSOIDIN B; BIOLOGICAL ACTIVITIES;

D O I：

10.1016/0031-9422(94)00626-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From Isodon loxothyrsa, one new diterpenoid, loxothyrin A, together with one known diterpenoid, adenolin B, from I, pleiophyllus, three known diterpenoids, coetsoidins A, B and G, and from I, adenoloma, one known diterpenoid, longikaurin F, were isolated. The structure determination of loxothyrin A, and the unambiguous NMR spectral assignments of the known compounds were made by a combination of 1D and 2D NMR techniques and computer modelling calculations. The isolates showed potent cytotoxic activities.

引用

页码：437 / 442

页数：6

共 19 条

[1] DELTA-POLARIZATION TRANSFER VIA LONG-RANGE COUPLING AS A SIMPLE ONE-DIMENSIONAL NMR TECHNIQUE FOR H-1-C-13 CORRELATION - APPLICATION TO THE DEFINITIVE ASSIGNMENT OF THE SYN AND ANTI C-13 DELTA-RESONANCES OF 2-SUBSTITUTED ADAMANTANES [J].