CHROMOSOMAL INSTABILITY IN BREAST-CANCER PATIENTS

被引：14

作者：

BARRIOS, L

CABALLIN, MR

MIRO, R

FUSTER, C

GUEDEA, F

SUBIAS, A

EGOZCUE, J

机构：

[1] UNIV AUTONOMA BARCELONA,HOSP SANTA CREU & SANT PAU,INST BIOL FONAMENTAL VICENT VILLAR PALASI,E-08193 BARCELONA,SPAIN

[2] UNIV AUTONOMA BARCELONA,HOSP SANTA CREU & SANT PAU,DEPT BIOL ANIM,E-08193 BARCELONA,SPAIN

[3] UNIV AUTONOMA BARCELONA,HOSP SANTA CREU & SANT PAU,SERV ONCOL,E-08193 BARCELONA,SPAIN

来源：

HUMAN GENETICS | 1991年 / 88卷 / 01期

关键词：

D O I：

10.1007/BF00204926

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have carried out cytogenetic studies, using the G-banding technique, in peripheral blood lymphocytes of 10 patients affected by breast carcinoma. The frequency of aberrant metaphases (7.36%) is significantly different from that of our laboratory controls (3.76% of aberrant metaphases) but not from that detected in patients suffering from bladder cancer (10.64%) and Hodgkin's disease (11.03%), two conditions that have previously been described as chromosomally unstable. Our results suggest that breast carcinoma patients show a degree of chromosomal instability that could be related to a predisposition to neoplastic disease.

引用

页码：39 / 41

页数：3

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