GENETIC-CONTROL OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS AT THE LEVEL OF CYTO-TOXIC LYMPHOCYTES IN GUINEA-PIGS

被引：7

作者：

BENNUN, A ^{[1
]}

COHEN, IR ^{[1
]}

机构：

[1] WEIZMANN INST SCI, DEPT CELL BIOL, IL-76100 REHOVOT, ISRAEL

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1982年 / 12卷 / 09期

关键词：

D O I：

10.1002/eji.1830120903

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To analyze immunologic mechanisms involved in experimental autoimmune encephalomyelitis (EAE), a system for studying the cytotoxic reaction of guinea pig lymphocytes against syngeneic macrophages pulsed with myelin basic protein (BP) was developed. Both EAE-susceptible strain 13 and EAE-resistant strain 2 in animals developed cytotoxicity directed against whole BP. Only strain 13 guinea pigs developed such cells in response to immunization with the encephalitogenic nonapeptide determinant of BP. Strain 2 macrophages appeared able to present the nonapeptide determinant to strain 13 lymphocytes. Anti-BP cytotoxic lymphocytes were recruited by anti-BP initiator lymphocytes.

引用

收藏

页码：709 / 713

页数：5

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