GENETIC-CONTROL OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS AT THE LEVEL OF CYTO-TOXIC LYMPHOCYTES IN GUINEA-PIGS

被引：7

作者：

BENNUN, A ^{[1
]}

COHEN, IR ^{[1
]}

机构：

[1] WEIZMANN INST SCI, DEPT CELL BIOL, IL-76100 REHOVOT, ISRAEL

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1982年 / 12卷 / 09期

关键词：

D O I：

10.1002/eji.1830120903

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To analyze immunologic mechanisms involved in experimental autoimmune encephalomyelitis (EAE), a system for studying the cytotoxic reaction of guinea pig lymphocytes against syngeneic macrophages pulsed with myelin basic protein (BP) was developed. Both EAE-susceptible strain 13 and EAE-resistant strain 2 in animals developed cytotoxicity directed against whole BP. Only strain 13 guinea pigs developed such cells in response to immunization with the encephalitogenic nonapeptide determinant of BP. Strain 2 macrophages appeared able to present the nonapeptide determinant to strain 13 lymphocytes. Anti-BP cytotoxic lymphocytes were recruited by anti-BP initiator lymphocytes.

引用

收藏

页码：709 / 713

页数：5

相关论文

共 22 条

[11] H-2 GENE COMPLEX RESTRICTS TRANSFER OF DELAYED-TYPE HYPERSENSITIVITY IN MICE [J].

MILLER, JFAP ;

VADAS, MA ;

WHITELAW, A ;

GAMBLE, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (12) :5095-5098

[12] INVITRO STUDIES ON CELL-MEDIATED CYTOTOXICITY BY MEANS OF A TERMINAL LABELING TECHNIQUE [J].

MORE, R ;

YRON, I ;

SASSON, SB ;

WEISS, DW .

CELLULAR IMMUNOLOGY, 1975, 15 (02) :382-391

[13] REGULATION OF T-CELL RESPONSE TO ECTROMELIA VIRUS-INFECTION .1. FEEDBACK SUPPRESSION BY EFFECTOR T-CELLS [J].

PANG, T ;

BLANDEN, RV .

JOURNAL OF EXPERIMENTAL MEDICINE, 1976, 143 (03) :469-481

[14]

Paterson P.Y., 1976, TXB IMMUNOPATHOLOGY, V2nd, P179

[15]

SCHWARTZ BD, 1976, TRANSPLANT REV, V30, P174

[16] SENSITIZATION OF LYMPHOID CELLS IN TISSUE CULTURE TO EAE ENCEPHALITOGEN [J].

SEIDEN, GE .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1967, 26 (04) :551-&

[17] CELL-MEDIATED LYMPHOLYSIS OF TRINITROPHENYL-MODIFIED AUTOLOGOUS LYMPHOCYTES - EFFECTOR CELL SPECIFICITY TO MODIFIED CELL-SURFACE COMPONENTS CONTROLLED BY H-2K AND H-2D SEROLOGICAL REGIONS OF MURINE MAJOR HISTOCOMPATIBILITY COMPLEX [J].

SHEARER, GM ;

REHN, TG ;

GARBARINO, CA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1975, 141 (06) :1348-1364

[18] REGULATION OF AUTOSENSITIZATION TO ENCEPHALITOGENIC MYELIN BASIC-PROTEIN BY MACROPHAGE-ASSOCIATED AND SOLUBLE-ANTIGEN [J].

STEINMAN, L ;

COHEN, IR ;

TEITELBAUM, D ;

ARNON, R .

NATURE, 1977, 265 (5590) :173-175

[19] STRAIN DIFFERENCES IN SUSCEPTIBILITY TO EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS AND IMMUNE-RESPONSE TO ENCEPHALITOGENIC DETERMINANT IN INBRED GUINEA-PIGS [J].

TEITELBAUM, D ;

WEBB, C ;

ARNON, R ;

SELA, M .

CELLULAR IMMUNOLOGY, 1977, 29 (02) :265-271

[20] THYMUS-DERIVED LYMPHOCYTES CONTROL THE EXPRESSION OF IMMUNOGENIC PROPERTIES OF PERITONEAL-MACROPHAGES [J].

TZEHOVAL, E ;

SEGAL, S ;

FELDMAN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (08) :4056-4060