THE MULTIDRUG RESISTANCE (MDR1) GENE-PRODUCT FUNCTIONS AS AN ATP CHANNEL

被引：365

作者：

ABRAHAM, EH

PRAT, AG

GERWECK, L

SENEVERATNE, T

ARCECI, RJ

KRAMER, R

GUIDOTTI, G

CANTIELLO, HF

机构：

[1] HARVARD UNIV,DEPT BIOCHEM & MOLEC BIOL,CAMBRIDGE,MA 02138

[2] MASSACHUSETTS GEN HOSP,RENAL UNIT,BOSTON,MA 02129

[3] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02129

[4] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115

[5] CHILDRENS HOSP MED CTR,BOSTON,MA 02115

[6] HARVARD UNIV,SCH MED,JOINT CTR RADIAT THERAPY,BOSTON,MA 02115

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 01期

关键词：

D O I：

10.1073/pnas.90.1.312

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The multidrug resistance (mdr1) gene product, P-glycoprotein, is responsible for the ATP-dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells. The data presented here show that cells with increased levels of the P-glycoprotein release ATP to the medium in proportion to the concentration of the protein in their plasma membrane. Furthermore, measurements of whole-cell and single-channel currents with patch-clamp electrodes indicate that the P-glycoprotein serves as an ATP-conducting channel in the plasma membrane. These findings suggest an unusual role for the P-glycoprotein.

引用

页码：312 / 316

页数：5

共 53 条

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