Bumetanide and bicarbonate increase short-circuit current in fetal lung epithelium

被引：6

作者：

Marunaka, Y ^{[1
]}

Doi, YS ^{[1
]}

Nakahari, T ^{[1
]}

机构：

[1] UNIV TORONTO, HOSP SICK CHILDREN,FAC MED,RES INST,DIV RESP RES, TORONTO, ON M5G 1X8, CANADA

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1995年 / 26卷 / 07期

关键词：

amiloride; beta-adrenergic agonist; rat; terbutaline; type II cells;

D O I：

10.1016/0306-3623(95)00032-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. We studied the effects of bumetanide (a Na+/K+/2Cl(-) cotransport inhibitor) and HCO3- on beta-adrenergic-agonist-stimulated short-circuit current (beta-I-sc) in rat fetal distal lung epithelium (FDLE). 2. Bumetanide significantly increased beta-I-sc in the absence of amiloride but decreased it in its presence. The amiloride- and bumetanide-insensitive beta-I-sc was diminished by a removal of HCO3- in the bathing solution. 3. Our results suggest that bumetanide stimulates the amiloride-sensitive beta-I-sc in FDLE and that the amiloride-insensitive beta-I-sc is composed of two different pathways: bumetanide-sensitive and HCO3--dependent Cl- secretion in FDLE.

引用

页码：1513 / 1517

页数：5

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