DISTRIBUTION OF FENRETINIDE IN THE MAMMARY-GLAND OF BREAST-CANCER PATIENTS

被引：73

作者：

MEHTA, RG ^{[1
]}

MOON, RC ^{[1
]}

HAWTHORNE, M ^{[1
]}

FORMELLI, F ^{[1
]}

COSTA, A ^{[1
]}

机构：

[1] IST NAZL TUMORI,I-20133 MILAN,ITALY

来源：

EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 02期

关键词：

D O I：

10.1016/0277-5379(91)90471-O

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fenretinide has been used orally as a chemopreventive retinoid in a trial for women at risk of developing contralateral breast cancer. The levels of fenretinide and its metabolites were measured in the breast tissue obtained at surgery from women in the trial. Fenretinide was concentrated by breast tissue. Two major metabolites were detected in the tissue extract, one co-eluting with N-(4-methoxyphenyl)retinamide (4-MPR), and the other, more polar, eluting at 17 min under the conditions used. This metabolite remains unidentified. Division of the breast tissue into epithelial cells and fat fractions revealed that fenretinide and the metabolite at the 17 min peak were concentrated in the epithelial cells, whereas 4-MPR was principally localised in the fat compartment. Thus fat may serve as a storage compartment for the retinoid.

引用

页码：138 / 141

页数：4