DOPAMINE INCREASE IN THE NUCLEUS-ACCUMBENS OF RATS EXPOSED TO HIGH-PRESSURE

被引：11

作者：

ABRAINI, JH ^{[1
]}

ROSTAIN, JC ^{[1
]}

机构：

[1] FAC MED NORD,BIOL HAUTES PRESS LAB,CNRS,URA 1330,BLVD PIERRE DRAMARD,F-13326 MARSEILLE 15,FRANCE

来源：

NEUROREPORT | 1991年 / 2卷 / 05期

关键词：

NUCLEUS ACCUMBENS; DOPAMINE; VOLTAMMETRY;

D O I：

10.1097/00001756-199105000-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

When human divers and experimental animals are exposed to high pressure, they develop the high pressure neurological syndrome (HPNS) characterized by electroencephalographic changes, sleep and behavioral disturbances. Free-moving rats chronically implanted in the nucleus accumbens with carbon electrodes essentially selective to dopamine (DA) were compressed to 80 bar. Compression was found to lead to a sustained increase in extracellular DA level (+88%), then during the stay and decompression phases, values progressively decreased. These results are discussed in the field of the involvement of the DA meso-limbic pathways in the occurrence of some of the behavioral disturbances of HPNS in rats including hyperlocomotor activity and hoarding behavior.

引用

页码：233 / 235

页数：3