EXTRATHYMIC DIFFERENTIATION OF INTRAEPITHELIAL LYMPHOCYTES - GENERATION OF A SEPARATE AND UNEQUAL T-CELL REPERTOIRE

被引：115

作者：

LEFRANCOIS, L

机构：

[1] Dept of Cell Biology, The Upjohn Company, Kamazoo

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 12期

关键词：

D O I：

10.1016/0167-5699(91)90015-L

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A significant number of intraepithelial intestinal T cells appear to mature extrathymically. In this paper, Leo Lefrancois discusses the implication of this for T-cell receptor selection and repertoire generation. He goes on to develop the concept that such cells may constitute discrete subsets of organ-specific lymphocytes, with unique T-cell receptor repertoires that may be evolutionary antecedents of thymus-derived T cells.

引用

收藏

页码：436 / 438

页数：3

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