EFFECTS OF SINGLE-DOSE ULTRAVIOLET-RADIATION ON SKIN SUPEROXIDE-DISMUTASE, CATALASE, AND XANTHINE-OXIDASE IN HAIRLESS MICE

被引：97

作者：

PENCE, BC ^{[1
]}

NAYLOR, MF ^{[1
]}

机构：

[1] TEXAS TECH UNIV, HLTH SCI CTR, DEPT DERMATOL, LUBBOCK, TX 79430 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1990年 / 95卷 / 02期

关键词：

D O I：

10.1111/1523-1747.ep12478037

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The effects of a single exposure to UVB radiation on skin antioxidant enzymes and superoxide-generating xanthine oxidase were examined in Skh:HR-1 hairless mice. Significant decreases in superoxide dismutase (SOD) and catalase (CAT) were observed by 12 h after UV irradiation and remained depressed for up to 72 h. No induction of xanthine dehydrogenase (XD) or xanthine oxidase (XO) occurred with UV treatment, although significant hyperplasia was evident. Ornithine decarboxylase was induced after UV irradiation as has been previously reported. These results demonstrate significant biochemical effects of a single dose of UVB on murine epidermis, especially in terms of antioxidant defenses. © 1990.

引用

页码：213 / 216

页数：4

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