STEREOSPECIFIC SYNTHESIS OF 4-FLUOROGLUTAMIC ACIDS

被引：40

作者：

AVENT, AG ^{[1
]}

BOWLER, AN ^{[1
]}

DOYLE, PM ^{[1
]}

MARCHAND, CM ^{[1
]}

YOUNG, DW ^{[1
]}

机构：

[1] UNIV SUSSEX,SCH CHEM & MOLEC SCI,BRIGHTON BN1 9QJ,E SUSSEX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 11期

关键词：

4-FLUOROGLUTAMATE; STEREOCHEMISTRY; CONFORMATIONAL ISOMERISM; INHIBITOR; AMINO ACID;

D O I：

10.1016/S0040-4039(00)91661-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereospecific route to 4-fluoroglutamic acids from pyroglutamic acid has been devised and variable temperature H-1-nmr spectroscopic studies have explained apparent inconsistencies in the stereochemical outcome of steps in a synthesis of 4-fluoroglutamic acids from hydroxyprolines.

引用

页码：1509 / 1512

页数：4

共 24 条

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