NEURONAL DEATH AFTER PERINATAL ASPHYXIA

被引：10

作者：

DEHAAN, HH

HASAART, THM

机构：

[1] Department of Obstetrics and Gynecology, University Hospital, 6202 AZ Maastricht

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1995年 / 61卷 / 02期

关键词：

ASPHYXIA; CEREBRAL DAMAGE; NEURONAL DEATH; OXYGEN DERIVED FREE RADICALS; REVIEW;

D O I：

10.1016/0301-2115(95)02127-S

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

During perinatal asphyxia several mechanisms aim to limit cerebral damage. However, when the degree of asphyxia passes beyond a certain threshold, brain damage is inevitable. This review focuses on the various factors determining the final cerebral outcome. Metabolic and biochemical events, such as the intracellular level of calcium, the formation of oxygen derived free radicals, the release of excitotoxic neurotransmitters and the interrelationship of these parameters are discussed. Furthermore, steps possibly useful to pharmacologic intervention aiming to reduce cerebral damage are presented.

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页码：123 / 127

页数：5

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