MOSSY FIBER LONG-TERM POTENTIATION SHOWS SPECIFICITY BUT NO APPARENT COOPERATIVITY

被引：32

作者：

ZALUTSKY, RA

NICOLL, RA

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT PHARMACOL,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143

来源：

NEUROSCIENCE LETTERS | 1992年 / 138卷 / 01期

关键词：

HIPPOCAMPUS; MOSSY FIBER; CA3; LONG-TERM POTENTIATION; COOPERATIVITY; SPECIFICITY;

D O I：

10.1016/0304-3940(92)90503-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Specificity in long-term potentiation (LTP) means that synapses onto a postsynaptic cell can potentiate independently of one another. Cooperativity refers to a requirement that some threshold number of afferents be co-activated to evoke LTP with a high-frequency stimulus. The induction of long-term potentiation (LTP) at the associational/commissural synapses onto hippocampal CA3 pyramidal cells shows clear cooperativity. LTP of mossy fiber inputs to these cells does not. Mossy fiber LTP does show synapse specificity. These results bear on the cellular mechanisms and the functions of mossy fiber LTP.

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页码：193 / 197

页数：5

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